If its a really long tank I'd suggest a 2x6 or 8 for the length support. Beams work better for supporting weight horizontally. I have a smaller tank but I still overbuilt. I used 2x6 for the lengths, 2x4 for the width, and 4x4 for the height/posts.
Assuming your measurements are in inches, thats a 450 gallon tank, which will be 3735 pounds of water alone! That's 186 pounds per square foot. I tried to google for a span calculator for 2x4, 2x6, 2x8 etc. The best thing I could find was this:
http://www.awc.org/technical/spantables/tutorial.htm Its a good read.